Ledderhose Disease: Causes, Symptoms, Treatment, Prevention, & More - Healthroid

Ledderhose Disease: Causes, Symptoms, Treatment, Prevention, & More

Priyank Pandey
Written by Priyank Pandey on September 23, 2022

Ledderhose disease, also known as plantar fibromatosis, is a condition characterized by the formation of the firm, non-cancerous (benign) lumps in the soft tissues of the bottom of the foot. The lumps, or nodules, are made up of thickened bands of tissue called collagen that form around the tendons and ligaments in the foot. Ledderhose disease most often affects middle-aged men and women, although it can occur at any age. The cause of Ledderhose disease is unknown.

There are three stages of Ledderhose disease:

Stage 1: One or more small (~1 cm), rubbery lumps form on the bottom of the foot, usually near the base of the toes. These lumps may be tender to the touch. There may be a pain in the bottom of the foot, but it is mild. The lumps may remain unchanged for months or years.

Stage 2: The lumps grow and become larger and more rubbery. They may begin to hurt and cause a limp. The lumps may become warm and red. They may become inflamed, filled with pus, or ulcerated.

Stage 3: The disease progresses to the point that the entire bottom of the foot is covered by large, rubbery lumps that are painful and tender.


Ledderhose disease is a condition that results in the thickening and hardening of connective tissues, most commonly affecting the hands and feet. The exact cause of Ledderhose disease is unknown, but it is believed to be related to a combination of genetic and environmental factors.

Ledderhose disease usually affects adults over the age of 40 and is more common in men than women. The condition typically begins with the development of small lumps under the skin on the palms of the hands or soles of the feet. These lumps may be tender or painless at first, but can eventually lead to thickened cords of tissue that can contract and deform the affected body part.


There are three main symptoms of Ledderhose disease: plantar fibromatosis, which is the growth of noncancerous tumors in the soles of your feet; Dupuytren’s contracture, which is the thickening and tightening of tissue in your palm that can limit finger movement; and carpal tunnel syndrome, which is a condition that causes numbness, tingling and weakness in your hand because of pressure on a nerve in your wrist.

Plantar fibromatosis usually develops gradually, with symptoms starting as small, pea-sized lumps under the skin on the soles of your feet. The lumps may grow larger and become more numerous over time. They may be tender or painful, especially when you walk barefoot or wear shoes that rub against them.


Ledderhose disease is a condition that results in the formation of fibrous tissue in the plantar fascia, which is the connective tissue that runs along the bottom of the foot. The condition can cause pain and difficulty walking. The exact cause of Ledderhose disease is unknown, but it is thought to be related to overuse or injury to the foot.

Ledderhose disease is usually diagnosed based on a physical examination and medical history. X-rays may also be used to rule out other conditions that can cause similar symptoms, such as heel spurs or arthritis. In some cases, a biopsy of the affected tissue may be necessary to confirm the diagnosis.

There is no cure for Ledderhose disease, but treatments are available to help relieve symptoms and improve quality of life.


There is no definitive treatment for Ledderhose disease, as the condition can vary widely in terms of symptoms and severity. However, there are a number of treatment options that may be effective in managing the condition and alleviating symptoms.

One common approach is to wear shoes or other forms of foot protection that help to offload pressure from the affected areas. This can help to reduce pain and prevent further tissue damage. Physical therapy may also be recommended to help stretch and strengthen the muscles and tissues around the affected area. The doctor may prescribe you NSAIDs such as ibuprofen or naproxen to reduce pain. Rest, ice, and stretching exercises may also help.

In more severe cases, surgery may be necessary to remove diseased tissue or correct deformities. However, this is typically only considered when other treatment options have failed to provide relief.

Ledderhose Disease


There is no known prevention for Ledderhose disease. The condition is thought to be caused by a combination of genetics and environmental factors, neither of which can be controlled. While there is no cure for Ledderhose disease, avoiding injury to your feet, Drinking alcohol in moderation early diagnosis, and treatment can help prevent the progression of the condition and minimize its symptoms.

Risk Factors

There are several risk factors for Ledderhose disease, including:

-Family history: Ledderhose disease can be hereditary, so if you have a family member with the condition, you may be at increased risk.

-Age: The condition is most commonly diagnosed in middle-aged adults.

-Occupation: People who work in occupations that involve repeated hand or foot movements (such as typing or manual labor) may be at higher risk for developing Ledderhose disease.

-Gender: Men are more likely to develop Ledderhose disease than women.


The most common complication of Ledderhose disease is the formation of nodules or fibrous tissue in the plantar fascia, the thick band of tissue that runs across the bottom of your foot and connects your heel bone to your toes. This can lead to pain and stiffness in the affected foot and make it difficult to walk. Other complications include Infection, trouble wearing shoes, and scars that may be painful.


There are a few key points to remember about Ledderhose disease. First, it is a condition that affects the connective tissues in the feet. This can lead to pain, swelling, and deformity in the affected area. Second, Ledderhose disease is a progressive condition, meaning that it will typically get worse over time. Finally, while there is no cure for Ledderhose disease, there are treatments available that can help to manage the symptoms and slow down the progression of the condition.

Published on September 23, 2022 and Last Updated on September 23, 2022 by: Mayank Pandey

Priyank Pandey
Written by Priyank Pandey on September 23, 2022

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